A powerful intervention: general practitioners' use of sickness certification in depression

<b>Background</b> Depression is frequently cited as the reason for sickness absence, and it is estimated that sickness certificates are issued in one third of consultations for depression. Previous research has considered GP views of sickness certification but not specifically in relation to depression. This study aimed to explore GPs views of sickness certification in relation to depression.<p></p> <b>Methods</b> A purposive sample of GP practices across Scotland was selected to reflect variations in levels of incapacity claimants and antidepressant prescribing. Qualitative interviews were carried out between 2008 and 2009.<p></p> <b>Results</b> A total of 30 GPs were interviewed. A number of common themes emerged including the perceived importance of GP advocacy on behalf of their patients, the tensions between stakeholders involved in the sickness certification system, the need to respond flexibly to patients who present with depression and the therapeutic nature of time away from work as well as the benefits of work. GPs reported that most patients with depression returned to work after a short period of absence and that it was often difficult to predict which patients would struggle to return to work.<p></p> <b>Conclusions</b> GPs reported that dealing with sickness certification and depression presents distinct challenges. Sickness certificates are often viewed as powerful interventions, the effectiveness of time away from work for those with depression should be subject to robust enquiry

Host Galaxy Evolution in Radio-Loud AGN

We investigate the luminosity evolution of the host galaxies of radio-loud AGN through Hubble Space Telescope imaging of 72 BL Lac objects, including new STIS imaging of nine z > 0.6 BL Lacs. With their intrinsically low accretion rates and their strongly beamed jets, BL Lacs provide a unique opportunity to probe host galaxy evolution independent of the biases and ambiguities implicit in quasar studies. We find that the host galaxies of BL Lacs evolve strongly, consistent with passive evolution from a period of active star formation in the range 0.5 <~ z <~ 2.5, and inconsistent with either passive evolution from a high formation redshift or a non-evolving population. This evolution is broadly consistent with that observed in the hosts of other radio-loud AGN, and inconsistent with the flatter luminosity evolution of quiescent early types and radio-quiet hosts. This indicates that active star formation, and hence galaxy interactions, are associated with the formation for radio-loud AGN, and that these host galaxies preferentially accrete less material after their formation epoch than galaxies without powerful radio jets. We discuss possible explanations for the link between merger history and the incidence of a radio jet.Comment: 37 pages, 8 figures, accepted for publication in ApJ, for full PDF incl. figures see http://www.ph.unimelb.edu.au/~modowd/papers/odowdurry2005.pd

Response of the Aerodyne Aerosol Mass Spectrometer to Inorganic Sulfates and Organosulfur Compounds: Applications in Field and Laboratory Measurements

Organosulfur compounds are important components of secondary organic aerosols (SOA). While the Aerodyne high-resolution time-of-flight aerosol mass spectrometer (AMS) has been extensively used in aerosol studies, the response of the AMS to organosulfur compounds is not well-understood. Here, we investigated the fragmentation patterns of organosulfurs and inorganic sulfates in the AMS, developed a method to deconvolve total sulfate into components of inorganic and organic origins, and applied this method in both laboratory and field measurements. Apportionment results from laboratory isoprene photooxidation experiment showed that with inorganic sulfate seed, sulfate functionality of organic origins can contribute ∼7% of SOA mass at peak growth. Results from measurements in the Southeastern U.S. showed that 4% of measured sulfate is from organosulfur compounds. Methanesulfonic acid was estimated for measurements in the coastal and remote marine boundary layer. We explored the application of this method to unit mass-resolution data, where it performed less well due to interferences. Our apportionment results demonstrate that organosulfur compounds could be a non-negligible source of sulfate fragments in AMS laboratory and field data sets. A reevaluation of previous AMS measurements over the full range of atmospheric conditions using this method could provide a global estimate/constraint on the contribution of organosulfur compounds

The HST Survey of BL Lacertae Objects. II. Host Galaxies

We have used the HST WFPC2 camera to survey 132 BL Lac objects comprising seven complete radio-, X-ray-, and optically-selected samples. We obtained useful images for 110 targets spanning the redshift range 0 < z < 1.3. In two thirds of the BL Lac images, host galaxies are detected, including nearly all for z < 0.5 (58 of 63). The highest redshift host galaxy detected is in a BL Lac object at z=0.664. In 58 of the 72 resolved host galaxies, a de Vaucouleurs profile is significantly preferred, at >99% confidence, over a pure exponential disk; the two fits are comparable in the remaining 14 cases. These results limit the number of disk systems to at most 8% of BL Lacs (at 99% confidence), and are consistent with all BL~Lac host galaxies being ellipticals. The detected host galaxies are luminous ellipticals with a median absolute K-corrected magnitude of M_R= -23.7 +- 0.6 mag, at least one magnitude brighter than M* and comparable to brightest cluster galaxies. The galaxy morphologies are generally smooth and undisturbed, with small or negligible ellipticities (<0.2). There is no correlation between host galaxy and observed nuclear magnitude or estimated jet power corrected for beaming. If black hole mass is correlated linearly with bulge mass in general, this implies a large range in Eddington ratio. Present data strongly support the unification picture with FR I galaxies constituting the bulk of the parent population of BL Lac objects.Comment: Accepted for publication on ApJ. 38 pages, 8 figure

Simultaneous Detection of Alkylamines in the Surface Ocean and Atmosphere of the Antarctic Sympagic Environment

Measurements of alkylamines from seawater and atmospheric samples collected simultaneously across the Antarctic Peninsula, South Orkney and South Georgia Islands are reported. Concentrations of mono-, di-, and trimethylamine (MMA, DMA, and TMA, respectively), and their precursors, the quarternary amines glycine betaine and choline, were enhanced in sympagic seawater samples relative to ice-devoid pelagic ones, suggesting the microbiota of sea ice and sea ice-influenced ocean is a major source of these compounds. Primary sea-spray aerosol particles artificially generated by bubbling seawater samples were investigated by aerosol time-of-flight mass spectrometry (ATOFMS) of single particles; their mixing state indicated that alkylamines were aerosolized with sea spray from dissolved and particulate organic nitrogen pools. Despite this unequivocal sea spray-associated source of alkylamines, ATOFMS analyses of ambient aerosols in the sympagic region indicated that the majority (75–89%) of aerosol alkylamines were of secondary origin, that is, incorporated into the aerosol after gaseous air–sea exchange. These findings show that sympagic seawater properties are a source of alkylamines influencing the biogenic aerosol fluxed from the ocean into the boundary layer; these organic nitrogen compounds should be considered when assessing secondary aerosol formation processes in Antarctica

On the selection of AGN neutrino source candidates for a source stacking analysis with neutrino telescopes

The sensitivity of a search for sources of TeV neutrinos can be improved by grouping potential sources together into generic classes in a procedure that is known as source stacking. In this paper, we define catalogs of Active Galactic Nuclei (AGN) and use them to perform a source stacking analysis. The grouping of AGN into classes is done in two steps: first, AGN classes are defined, then, sources to be stacked are selected assuming that a potential neutrino flux is linearly correlated with the photon luminosity in a certain energy band (radio, IR, optical, keV, GeV, TeV). Lacking any secure detailed knowledge on neutrino production in AGN, this correlation is motivated by hadronic AGN models, as briefly reviewed in this paper. The source stacking search for neutrinos from generic AGN classes is illustrated using the data collected by the AMANDA-II high energy neutrino detector during the year 2000. No significant excess for any of the suggested groups was found.Comment: 43 pages, 12 figures, accepted by Astroparticle Physic

Response to the editorial by Dr Geraghty

This article is written in response to the linked editorial by Dr Geraghty about the adaptive Pacing, graded Activity and Cognitive behaviour therapy; a randomised Evaluation (PACE) trial, which we led, implemented and published. The PACE trial compared four treatments for people diagnosed with chronic fatigue syndrome. All participants in the trial received specialist medical care. The trial found that adding cognitive behaviour therapy or graded exercise therapy to specialist medical care was as safe as, and more effective than, adding adaptive pacing therapy or specialist medical care alone. Dr Geraghty has challenged these findings. In this article, we suggest that Dr Geraghty’s views are based on misunderstandings and misrepresentations of the PACE trial; these are corrected

The HST Survey of BL~Lacertae Objects. IV. Infrared Imaging of Host Galaxies

The HST NICMOS Camera 2 was used for H-band imaging of 12 BL Lacertae objects taken from the larger sample observed with the WFPC2 in the R band (Urry et al. 2000; Scarpa et al. 2000). Ten of the 12 BL Lacs are clearly resolved, and the detected host galaxies are large, bright ellipticals with average H-band absolute magnitude M=-26.2+-0.45 mag and effective radius 10+-5 kpc. The rest-frame integrated color of the host galaxies is on average R-H=2.3+-0.3, consistent with the value for both radio galaxies and normal, non-active elliptical galaxies, and indicating the dominant stellar population is old. The host galaxies tend to be bluer in their outer regions than in their cores, with average color gradient Delta(R-H)/Delta(log r)=-0.2 mag, again consistent with results for normal non-active elliptical galaxies. The infrared Kormendy relation, derived for the first time for BL Lac host galaxies, is m(e) = 3.8*log(R)+14.8 (where m(e) is the surface brightness at the effective radius R), fully in agreement with the relation for normal ellipticals. The close similarity between BL Lac host galaxies and normal ellipticals suggests the active nucleus has surprisingly little effect on the host galaxy. This supports a picture in which all elliptical galaxies harbor black holes which can be actively accreting for some fraction of their lifetime.Comment: Accepted for publication on ApJ. 25 pages, 7 figure

Conversion of Iodide to Hypoiodous Acid and Iodine in Aqueous Microdroplets Exposed to Ozone

Halides are incorporated into aerosol sea spray, where they start the catalytic destruction of ozone (O3) over the oceans and affect the global troposphere. Two intriguing environmental problems undergoing continuous research are (1) to understand how reactive gas phase molecular halogens are directly produced from inorganic halides exposed to O3 and (2) to constrain the environmental factors that control this interfacial process. This paper presents a laboratory study of the reaction of O3 at variable iodide (I–) concentration (0.010–100 μM) for solutions aerosolized at 25 °C, which reveal remarkable differences in the reaction intermediates and products expected in sea spray for low tropospheric [O3]. The ultrafast oxidation of I– by O3 at the air–water interface of microdroplets is evidenced by the appearance of hypoiodous acid (HIO), iodite (IO2–), iodate (IO3–), triiodide (I3–), and molecular iodine (I2). Mass spectrometry measurements reveal an enhancement (up to 28%) in the dissolution of gaseous O3 at the gas–liquid interface when increasing the concentration of NaI or NaBr from 0.010 to 100 μM. The production of iodine species such as HIO and I2 from NaI aerosolized solutions exposed to 50 ppbv O3 can occur at the air–water interface of sea spray, followed by their transfer to the gas-phase, where they contribute to the loss of tropospheric ozone